Aim: Identify potential sites of ribosome specialisation and determine common mechanisms across eukaryotes.
We will extract key evolutionary features from the sequences of ribosomal proteins and associated proteins, identifying levels of conservation of these features across all evolutionary depths from eukaryote-conserved to Kingdom-conserved (plants, fungi, animals) and within Kingdom-conserved. Integrating data from across the program of research, and combining traditional comparative genomics and phylogenomics with machine learning techniques, we will generate hypotheses of ribosomal specialisation which the rest of the RiboCode team will test from a structural and functional perspective.
Mapping the information from these evolutionary questions onto protein products, structures and interactions, our results will inform and be informed by work in other themes involving experimental models.
Professor Mary O’Connell (she/her)
Dr Alan Beavan (he/him)
Dr Elton Vasconcelos (he/him)