Unlocking the secrets of specialised ribosomes across eukaryotes

RiboCode is a multi-institution, cross-disciplinary research project aiming to transform our understanding of specialised ribosomes. Specialised ribosomes are groups of ribosomes that specifically translate a set of mRNAs and represent a new regulatory mechanism in gene expression.

Using cutting-edge scientific techniques, we aim to understand the detailed molecular mechanisms of specialisation and determine common features across eukaryotes. We will study ribosome specialisation from an evolutionary, functional (translational outcome) and structural perspective, using different eukaryotic model systems (yeast, Drosophila, Arabidopsis and human cells) that cover >1 billion years of evolution. We will also develop novel tools, including nanopore-based approaches, to characterise specialised ribosomes in single cells.